Based on the GWAS results, we evaluated the allelic frequencies of the NOTCH4 rs2071286 and the HLA-II rs9461776 SNPs, in a wide cohort of patients with different HCV-related LPDs with circulating cryoglobulins, with and without vasculitis, or with HCV− related NHL, comparing them to a group of HCV+ patients without LPDs. The gene discussed is NOTCH4; the disease is non-Hodgkin lymphoma.