For instance, SUMOylation inhibited inflammation by silencing IFN expression and LPS-induced anti-viral response was enhanced by SUMO deficiency in bone marrow cells [10]; SUMOylation of IRF2 regulated its own transcription to inhibit IRF1 activity in 293 cells [11]; Over-expressed SUMO1 and SUMO2 enhanced Singapore grouper iridovirus and red-spotted grouper nervous necrosis virus replication during viral infection in vitro [12] and SUMO expression reduced interferon synthesis upon rabies virus or vesicular stomatitis virus infection by protecting MxA protein from degradation [13]. This evidence concerns the gene IFNA1 and viral infectious disease.