IRF1 and infection: The results showed that transcriptional activators IRF1 and IRF7 were statistically upregulated as early as 24 h post infection in cells W/O 2-D08 treatment (Figure 7A and 7C), as well as their activating target IFNI (Figure 7E); in contrast, GCRV infection induced no expression of IFN-transcriptional inhibitor IRF2, which could only be significantly stimulated in cells treated with both 2-D08 and GCRV (Figure 7B) or 2-D08 only (Figure 6B).