We developed a metastatic HCC animal model with the Sk-Hep-1 cell line, which highly expresses CD44 (Figures 3–5), and found that CVV can attenuate cell migration (Figure 6) and thus regress the metastasis of highly metastatic Sk-Hep-1 cells (Figure 7) by inducing lower CD44 and thus reduced EMT marker expression. Here, CD44 is linked to hepatocellular carcinoma.