In Muc2 IECs, the data document decreased expression of Aconitase 1 (Aco1), and concomitant elevation of Acly, thus, increasing ATP-citrate-lyase (ACL)-dependent production of acetyl-CoA important for the proliferation of tumor cells and lipogenesis [21] (Figure 7D). This evidence concerns the gene MUC2 and neoplasm.