It is of note that these data are also consistent with the phenotype of double mutant Muc2−/−; Apc1638/N mice in which we demonstrated that there was a shift of tumor burden towards the colon, where we have also documented increased ROS producing phagocyte infiltration (Supplementary Figure 3); the phenotype of the double mutant Muc2/Apc mouse is reminiscent of the shift in tumor location observed in the Apc mutant mice challenged to mount of an inflammatory response. This evidence concerns the gene APC and neoplasm.