Intriguingly, we found that the two metrics have a very high correlation in each case (Figure 1A), suggesting that a significant portion of gene expression changes associated with ERBB2-, MYC- and CCND1-amplifying breast tumors are due to onco-passenger CNVs, which is also confirmed with an enrichment-based statistical test (Figure 1B). The gene discussed is CCND1; the disease is breast neoplasm.