Moreover, components of the translation machinery are mislocalized in SMN-depleted cells (Gabanella et al., 2016), and localization and translation of specific mRNAs are altered in primary neurons derived from SMA mice (Fallini et al., 2011, Fallini et al., 2016, Rossoll et al., 2003). This evidence concerns the gene SMN2 and proximal spinal muscular atrophy.