Similarly, ALS-associated protein aggregates affect the function of proteins that play an important role in regulating translation, such as FMRP (Blokhuis et al., 2016, Coyne et al., 2015), and mislocalization of axonal ribosomes occurs in ALS patients (Verheijen et al., 2014). Here, FMR1 is linked to amyotrophic lateral sclerosis.