Moreover, components of the translation machinery are mislocalized in SMN-depleted cells (Gabanella et al., 2016), and localization and translation of specific mRNAs are altered in primary neurons derived from SMA mice (Fallini et al., 2011, Fallini et al., 2016, Rossoll et al., 2003). The gene discussed is SMN1; the disease is proximal spinal muscular atrophy.