DNMT3B and Dravet syndrome: Results demonstrated that the levels of DNMT1 and DNMT3B mRNA were similar between DS and control samples (DNMT1 Mann–Whitney U-test: p = .4808; DNMT3B Mann–Whitney U-test: p = .2829), whereas DNMT3A and TDG genes were down-regulated in PBMCs from DS persons (DNMT3A Mann–Whitney U-test: p < .0001; TDG t-test: p = .0136; Figure 4).