To better characterize changes in relevant epigenetic enzymes connected with 5hmC in DS samples, the expression of the active DNA methyltransferase enzymes (DNMT1, DNMT3A, and DNMT3B) and of TDG, the main glycosylase involved in TET-mediated DNA demethylation, was also assessed. The gene discussed is DNMT1; the disease is Dravet syndrome.