In addition, due to the clear-cut reduction of DNMT3A in DS, we tested a possible association with the levels of 5hmC and TET genes demonstrating a positive correlation with TET2 (r = 0.2302, p = .03) and TET3 (r = 0.3895, p = .0002) but not with TET1 (r = 0.1259, p = .2396) and 5hmC (r = 0.07261, p = .5275; Supplementary Figure 4). This evidence concerns the gene TET2 and Dravet syndrome.