Jean's research demonstrated the increase of EMT was accompanied by the gradual disappearance of E-cadherin and elevated expression of vimentin.[32] This result was consistent with the results of our study, indicating that EMT phenomenon was observed in COPD patients, leading to cell membrane wall fibrosis and thickening of the cell wall, as well as the prompt remodeling of COPD airway or persistent and progressive airflow limitation, so as to participate in the COPD development.[33]. This evidence concerns the gene VIM and chronic obstructive pulmonary disease.