Details on data acquisition were published previously (Li H, Wetten S, Li L, St Jean PL, Upmanyu R, Surh L et al., Candidate single-nucleotide polymorphisms from a genome-wide association study of Alzheimer disease, Arch Neurol 2008; 65: 45–53 and Filippini N, Rao A, Wetten S, Gibson RA, Borrie M, Guzman D et al., Anatomically-distinct genetic associations of APOE epsilon4 allele load with regional cortical atrophy in Alzheimer’s disease, Neuroimage 2009; 44: 724–728). The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.