In another elegant study based on Reverse Phase Protein Array (RPPA) analysis of a cohort of 118 stage II colon cancer patients, an upregulation of three components of an activated PIK3/Akt pathway, namely phospho-Akt, S6RP, and phospho-4E-BP1, served as novel biomarkers for stage II colon cancer recurrence [125]. This evidence concerns the gene PIK3CG and malignant colon neoplasm.