RO60 and Sjogren syndrome: In Sjögren’s syndrome, pathogenesis relating to microorganism are proposed as follows [38]; (1) autoreactive T cells against Ro-60 could be activated by the peptides from oral, skin and gut bacteria; (2) immature B cells may not be appropriately removed to increase autoreactive B cells by failing access to gut-associated lymphoid tissue; (3) Ro-60 activated T cells could activate autoreactive B cells; and (4) dysbiosis of the gut microbiota could increase Th17 cells to migrate systemic circulation.