Neuropathologically, AD is characterized by increased accumulation of intracellular neurofibrillary tangles (NFTs) of hyperphosphorylated tau protein and of extracellular Aβ protein deposits (Aβ plaques) derived from amyloid precursor protein (APP) cleavage by γ-secretase and β-secretase [126,127,128]. This evidence concerns the gene MAPT and Alzheimer disease.