Obestatin, 23-amino-acid-peptide, colocalized with GHRL in human pancreas, decreased serum level of proinflammatory IL-1β and improved pancreatic blood flow in rats with cerulein-induced acute pancreatitis [13] as well as ischemia/reperfusion-induced acute pancreatitis of rats [14]. This evidence concerns the gene IL1B and acute pancreatitis.