On the other hand, a high concentration of DHA induces Ca2+-mediated activation of protein kinase C (PKC) isoforms (PKC-α, PKC-δ, PKC-ε, and PKC-ζ) and zymogen activation in the pancreatic acinar cells, which may promote acute pancreatitis [41]. The gene discussed is PRRT2; the disease is acute pancreatitis.