In addition to the loss of peripheral nerve function, a subset of patients with CMT2A have optic atrophy, suggesting that aberrations in OPA1 and Mfn2 converge on a common pathway that can lead to overlapping clinical outcomes causing optic nerve degeneration (Zuchner et al.,2004; Chung et al.,2006). This evidence concerns the gene MFN2 and Leber hereditary optic neuropathy.