In addition, Mfn2 has been implicated in the function of the retromer component vacuolar protein sorting‐35 (VPS35), mutations of which are linked to familial PD (Vilarino‐Guell et al.,2011; Zimprich et al.,2011) and also associated with AD (Small et al.,2005; Muhammad et al.,2008). This evidence concerns the gene MFN2 and Alzheimer disease.