PRKN and Parkinson disease: The Parkinson's disease‐associated proteins Parkin and PINK1 are involved in the ubiquitination of Mfn2 on damaged mitochondria (Tanaka et al.,2010; Gegg & Schapira, 2011), which promotes local fission of the mitochondrial network thereby segregating damaged mitochondria for autophagic clearance (Ziviani, Tao & Whitworth, 2010).