Although no specific Mfn2 mutations have been found to be causative for neurodegenerative diseases other than CMT2A and HMSN VI, emerging evidence has linked dysfunctional mitochondrial dynamics with Alzheimer's, Parkinson's, and Huntington's diseases (Wang et al.,2009a,b; Su et al.,2010). Here, MFN2 is linked to Parkinson disease.