It has been suggested that chronic alcohol abuse increases susceptibility to paracetamol toxicity due to CYP2E1 induction [95, 96, 98–101], that hepatic GSH is reduced leading to reduced NAPQI detoxification [95, 96, 98–101, 103, 104, 106, 109] and/or that glucuronidation is reduced leading to increased fractional oxidation [95–97]. This evidence concerns the gene CYP2E1 and alcohol abuse.