In this case report, bradykinin is most likely the mediator of angioedema episode because of at least four facts; there was no urticarial rash, the relatively long delay of angioedema onset after the simvastatin administration, the lack of improvement of the swelling with diphenhydramine, and the resolution of angioedema after simvastatin discontinuation. Here, KNG1 is linked to angioedema.