Furthermore, downregulation of NDRG2 alongside overexpression of miR-181c or LIF indicated a poorer overall survival in patients with CCA.In vivo andin vitro, it was shown that overexpression of NDRG2 was able to inhibit CCA cell proliferation, chemoresistance, and metastasis. The gene discussed is NDRG2; the disease is cholangiocarcinoma.