WFDC2 and endometrial cancer: Angioli found that, the sensitivity of HE4 in the diagnosis of endometrial cancer was 59.4%, but that of CA125 was only 19.8%.16 Omer improved the sensitivity of diagnosing endometrial cancer to 84% by using detection of multiple serum markers such as HE4, CA125, CA15-3, carcino embryonie antigen and CA19-9,17 suggesting combined detection of HE4 and CA125 were expected to provide more information for the diagnosis of endometrial cancer to make up the deficiency of single detection.