Angioli found that, the sensitivity of HE4 in the diagnosis of endometrial cancer was 59.4%, but that of CA125 was only 19.8%.16 Omer improved the sensitivity of diagnosing endometrial cancer to 84% by using detection of multiple serum markers such as HE4, CA125, CA15-3, carcino embryonie antigen and CA19-9,17 suggesting combined detection of HE4 and CA125 were expected to provide more information for the diagnosis of endometrial cancer to make up the deficiency of single detection. This evidence concerns the gene MUC16 and endometrial cancer.