AFP and Hyperbilirubinemia: Because estriol constitutes 60-70% of the total estrogens during pregnancy if the fetal adrenal and liver are functional and AFP is secreted during pregnancy from the fetal liver in a very high amount.1 We aimed to define if there is any relationship between second trimester serum markers and neonatal severe hyperbilirubinemia to protect the neonates from its neurological damage.