The first patient was reported by Imperato in 1958.3 Then in 1968, the first point mutation associated with this disease was identified.4 Currently, the pathogenesis of congenital dysfibrinogenemia is contributed to mutations in the three genes which encode fibrinogen together, that are genes FGA, FGB and FGG. The gene discussed is FGB; the disease is familial hypodysfibrinogenemia.