In order to overcome the insulin resistance, the two most studied drugs in NAFLD are metformin and pioglitazone and their efficacy was evident in meta analysisof numerous experimentaland clinicaltrials as both improves insulin sensitivity and reduces resistance in NAFLD.18 GTE also reduced insulin resistance by reducing HOMA-IR index and improved BMI and body weight in this study. This evidence concerns the gene INS and Insulin resistance.