This study aims to investigate the correlation between the expression of Ki67 and Topo IIα and the clinical pathological indicators of patients with breast cancer through detecting the expression of Ki67 and Topo IIα in the breast cancer tissues of 116 breast cancer patients who were admitted into our hospital, with the intention of providing a basis for the clinical treatment and prognosis determination. This evidence concerns the gene MKI67 and breast carcinoma.