KRT14 and cutaneous leishmaniasis: To investigate the impact of IL-4Rα signaling on keratinocytes in a protective Th1 cell differentiation against cutaneous leishmaniasis, we generated mice on the C57BL/6 genetic background that are genetically deficient in IL-4Rα expression on keratinocytes (KRT14CreIL-4Rα−/lox) using the Cre/LoxP recombination system under control of the KRT14 locus.