Also when TIL of patient #1 were cocultured with autologous (60.7%) or HLA-A2 matched allogeneic tumor cells (mel patient #2, 18.8%; mel 526, 12.0%) CD137 expression was high, but low after co-incubation with HLA-mismatched tumor cells (mel 888, 0.4%). The gene discussed is TNFRSF9; the disease is neoplasm.