The other four markers that were found for ZIKV-infected patients are phosphatidylinositol phosphates (Table 2); these help corroborate the role of Ang (1-7) in the immune response upon infection, since this peptide is responsible for activating the PI3K-AKT-mTOR pathway (Giani et al., 2007; Sampaio et al., 2007). This evidence concerns the gene AKT1 and infection.