ACE and viral infectious disease: Studies on viral infections, such as DENV and H5N1 have explored the inhibition of ACE (Tikellis et al., 2011; Zou et al., 2014; Hernández-Fonseca et al., 2015; Gu et al., 2016) and kinases involved in the PI3K-AKT-mTOR pathway (Easton et al., 2005; Tokuda et al., 2010; Liang et al., 2016); seven out of the eight biomarkers reported in this contribution are directly related to these enzymes, corroborating the relevance of these molecules and providing the targets in which substrate they work.