ERBB2 and neoplasm: The ErbB family receptors, including EGFR (ErbB1), HER2 (ErbB2), HER3 and HER4 are most frequently implicated in neoplasia and are known to turn on the PI3K/AKT pathway to regulate cell proliferation, survival, angiogenesis, migration and invasion (Arteaga and Engelman, 2014).