WIN55212-2 also increased PTPN6 expression and protein phosphatase A2 (PPA2) activity in SW480 colon cancer cells (Sreevalsan et al., 2011; Sreevalsan and Safe, 2013) and reduced the expression of the pro-tumorigenic transcription factors, specificity protein 1, 3, and 4 (SP1, SP3, and SP4). The gene discussed is SP1; the disease is colonic neoplasm.