Taking together anatomical evidence of OX innervation of mPFC subregions (Jin et al., 2016), the role of the mPFC as a key brain region involved in compulsivity/impulsivity (Fuster, 2001; Ambar and Chiavegatto, 2009), and pharmacological evidence linking OX to binge-drinking, we speculate that elevated basal OX activity in the IL area of the mPFC of the HD endophenotype might be linked to increased compulsivity/impulsivity and, consequently, spontaneous elevated EtOH binge-drinking in HD mice (Alcaraz-Iborra and Cubero, 2015). This evidence concerns the gene HCRT and Huntington disease.