PTEN and memory impairment: Interestingly, many of the hub genes’ individual expression patterns follow what is reported in the literature in respect to their potential role in aging associated learning and memory impairment, for example Camk1g, Dlg3, Dpp6, Mapk1, Mapre1, Ndfip2, Ppp2r2c, Pten, Prkacb and Rasgrp1. Some other hub genes such as Cdk5r1, Cntn1, Impact, Kcnab2, Scn2b and Stxbp1 may have more indirect role.