Other studies have shown that the CRH system in the mPFC plays an important role in stress-related behaviors, including anxiety, learning and memory and excessive alcohol consumption (Jaferi and Bhatnagar, 2007; George et al., 2012; Glaser et al., 2014; Gondré-Lewis et al., 2016; Uribe-Mariño et al., 2016). Here, CRH is linked to Anxiety.