Both rodent and human studies have implicated a role for CRH-BP in stress-related psychiatric disorders, including anxiety, depression and addiction (Enoch et al., 2008; Binder et al., 2010; Albrechet-Souza et al., 2015; Haass-Koffler et al., 2016; Ketchesin et al., 2016, 2017). Here, CRH is linked to major depressive disorder.