However, such a strategy should not only focused on Cx43 but also to other highly expressed Cxs in the CNS like Cx36 which appears to be involved in several neuronal injuries (autism, ischemia, retina, etc.; Welsh et al., 2005; Bargiotas et al., 2012; Ivanova et al., 2016). The gene discussed is GJD2; the disease is ischemia.