Moreover, palosuran, a UII-receptor antagonist that in our hands blunted the increase of CYP11B2 expression in the rat adrenocortical zona glomerulosa20, failed to lower BP and microalbuminuria in type 2 diabetic patients, which might argue against the relevance of UII27. The gene discussed is CYP11B2; the disease is type 2 diabetes mellitus.