A ribosomal protein (EMBRYO DEFECTIVE 3105 [EMB3105]), an actin-binding protein (NETWORKED 1A [NET1A]), a HEAT SHOCK PROTEIN 90-like protein (SHEPHERD [SHD]), and a membrane protein (TRN2) were also identified as possible CRC downstream targets22,36–38 (Fig. 2b). This evidence concerns the gene SHD and colorectal carcinoma.