Since the TRN2-misexpressing domain did not fully overlap with CRC (Fig. 4b, c and Supplementary Fig. 9g), this ectopic expression could be due to the presence of multiple transcriptional activators of TRN225, feedback regulation via the auxin pathway, and/or lack of mobile signals from YABBY gene activities46. Here, TNPO2 is linked to colorectal carcinoma.