The first SLC1A3 mutation (P290R)8, arose de novo in a single patient with episodic ataxia, hemiplegia with migraine, and epilepsy, impairs glutamate transport and enhances hEAAT1 anion currents27,32, likely reducing glial intracellular [Cl−]33,34. Here, SLC1A3 is linked to migraine disorder.