To further elucidate the clinical significance of CD19hi B cells in SLE and pemphigus, we performed the correlation analysis between the percentage of CD19hi B cells and clinical parameters related to the diseases diagnosis and severity, including serum total IgG/IgM, and anti-nuclear antibody (ANA), anti-nucleosome antibody, anti-double strand DNA (anti-dsDNA) antibody and SEDAI (Systemic Lupus Erythematosus Disease Activity Index) for SLE, as well as anti-Dsg1/Dsg3 antibodies for pemphigus. This evidence concerns the gene DSG3 and pemphigus.