TNXB and systemic lupus erythematosus: Furthermore, TNXB (previously reported for SLE, p = 2.5 × 10−7 in GCKD) and HLA-DRB1 (IgA risk locus, p = 4.6 × 10−11 in GCKD) showed independent associations with CKD attributed to T1DM.