P-JAK2, P-JNK, P-SRC, and P-c-ABL accumulate in fibroblasts in bleomycin- and TBRact-induced experimental fibrosis to a similar degree as in human SSc, confirming their suitability to study STAT3 signaling in SSc (Fig. 3e, f). The gene discussed is STAT3; the disease is fibrosis.