Next, a projected M. sympodialis model of the calcineurin complex inhibited by FKBP12-FK506 was built using SWISS-MODEL (36) based on homology with the amino acid sequences of the calcineurin A and B subunits and with FKBP12 constructed based on a crystal structure of the Coccidioides immitis FK506-inhibited calcineurin complex (Seattle Structural Genomics Center for Infectious Disease [SSGCID] et al., unpublished; SWISS-MODEL template library [SMTL] identifier [ID] or accession number 5b8i.1) (Fig. 7B and Movie S1). The gene discussed is FKBP1A; the disease is infectious disease.