One of the existing drugs was aspirin, which targets prostaglandin-endoperoxide synthase 1 (PTGS1) and PTGS2, and PTGS2 has a well described role in the pathogenesis of IPF.44, 45, 46, 47 Another of the drugs was dextromethorphan, a well known cough-suppressant that antagonises N-methyl-D-aspartate receptors.48 Here, PTGS1 is linked to idiopathic pulmonary fibrosis.