AKAP13 and idiopathic pulmonary fibrosis: In summary, we report a novel genome-wide significant association for IPF susceptibility with SNP rs62025270 and present evidence that this SNP might exert its effect via expression of the nearby gene AKAP13. AKAP13 is a RhoGEF that is known to interact with a central fibrogenic pathway—G protein-coupled receptor activation of RhoA—and expression is increased in fibrotic regions of lungs from patients with IPF.