Interestingly, a study by Mahmoodzadeh et al. using intact male and female mice with a cardiomyocyte-specific overexpression of ERα found that ERα increases expression of angiogenesis and lymphangiogenesis markers (such as VEGF and Lyve-1) and neovascularization in the peri-infarct area following MI in a sex-specific manner. This evidence concerns the gene ESR1 and myocardial infarction.