The median urine S100A4 levels were 7.35 ng/ml (IQR 1.6–23.9) for active LN visits, 0.97 ng/ml (IQR 0.4–2.2) for improved LN visits, and 0.32 ng/ml (IQR 0–0.6) for healthy control subjects. This evidence concerns the gene S100A4 and lobular neoplasia.