These include conflicting data on G308A SNP at the TNF gene (308GG genotype linked to better response to TNFi in two meta-analysis but refuted in another, larger and robust one [5]); and rs10919563 G > A SNP at the RA susceptibility-associated gene PTPRC (G allele associated with good response to TNFi in at least large three studies but not in another similarly large cohort and meta-analysis) [57–60]. The gene discussed is TNF; the disease is rheumatoid arthritis.