Moreover, upregulation of three NRs such as NR4A1, NR4A2, and NR4A3 can be used for the potential biomarkers for obesity while downregulation of NR1D1 can be used as a potential biomarker for obesity with rheumatoid arthritis as a complication. This evidence concerns the gene NR4A3 and obesity due to melanocortin 4 receptor deficiency.