Additionally, four other PRR families including C-type lectin receptors, retinoid acid-inducible gene 1 (RIG-1), absent in melanoma-2 (AIM-2), and receptor for advanced glycation end products (RAGE, also a receptor for high-mobility group box 1 (HMGB1)) have also been characterized [4]. The gene discussed is HMGB1; the disease is melanoma.