The NRs in the metabolic cardiovascular diseases group include RARA (cardiomyopathy), PPARD (diabetes mellitus), PPARG (diabetes mellitus, lipodystrophy, obesity, pulmonary hypertension), HNF4A (diabetes mellitus), NR2F2 (congenital heart defects), ESR1 (myocardial infarction), NR3C2 (hypertension), AR (obesity), and NR0B2 (obesity). This evidence concerns the gene PPARD and obesity due to melanocortin 4 receptor deficiency.