Similarly, among the top 10 pathways identified with the Ingenuity Pathway Analysis for the inflammasome/caspase-1 deficiency-downregulated NRs, seven pathways including circadian rhythm signaling, thyroid cancer signaling, Nur77 signaling in T lymphocytes, calcium-induced T-lymphocyte apoptosis, melatonin signaling, T helper cell differentiation, and non-small cell lung cancer signaling were specific. The gene discussed is CASP1; the disease is thyroid gland carcinoma.