The NRs in the metabolic cardiovascular diseases group include RARA (cardiomyopathy), PPARD (diabetes mellitus), PPARG (diabetes mellitus, lipodystrophy, obesity, pulmonary hypertension), HNF4A (diabetes mellitus), NR2F2 (congenital heart defects), ESR1 (myocardial infarction), NR3C2 (hypertension), AR (obesity), and NR0B2 (obesity). The gene discussed is RARA; the disease is obesity due to melanocortin 4 receptor deficiency.