ESR1 and obesity due to melanocortin 4 receptor deficiency: The NRs in the metabolic cardiovascular diseases group include RARA (cardiomyopathy), PPARD (diabetes mellitus), PPARG (diabetes mellitus, lipodystrophy, obesity, pulmonary hypertension), HNF4A (diabetes mellitus), NR2F2 (congenital heart defects), ESR1 (myocardial infarction), NR3C2 (hypertension), AR (obesity), and NR0B2 (obesity).