The median frequency of A1762T/G1764A dual mutations in BCP region was significantly higher in HBeAg negative hepatitis CHB (67%, **** p < 0.0001) as well as the immune active CHB group (6%, *p < 0.05) compared to the ACLF-CHB cohort (both 0% in both HBeAg positive and HBeAg negative) (Fig. 2a). The gene discussed is OPN1SW; the disease is Hepatitis.