SERPINA12 and diabetes mellitus: With macrovascular disease as the dependent variable, and gender, age, duration of diabetes, BMI, WHR, SBP, vaspin, hsCRP, TG, TC, LDL-C, HDL-C, FPG, FINS, HOMA-IR and HbA1C as independent variables, the analysis revealed a significant positive association between the presence of macrovascular disease and SBP and the duration of diabetes and HOMA-IR (P = 0.032, 0.045, 0.016, respectively), and a significant inverse association between the presence of macrovascular disease and HDL-C (P = 0.034) and serum vaspin concentration (P = 0.024) (Table 4).