Abe et al. [18, 19] demonstrated that PMX-DHP treatment eliminated activated neutrophils and humoral factors, including matrix metalloproteinase-9 (MMP-9) and high-mobility group box protein 1 (HMGB-1), from the blood circulation of patients with acute exacerbations of IPF. The gene discussed is MMP9; the disease is idiopathic pulmonary fibrosis.