A large number of studies have suggested that caspase-9 [29] and caspase-3 [30] are involved in the succession of myocardial infarction, also restriction of caspase-9 [31] and caspase-3 [32] can remarkably alleviate ischemia-induced myocardial apoptosis with heart function improvement. The gene discussed is CASP3; the disease is ischemia.