Another mice experiment indicated that allergen sensitization with low dose LPS (0.1 μg) and OVA induced type 2 responses with airway hyperresponsiveness, eosinophilic inflammation, and allergen-specific IgE up-regulation, but, again, sensitization with high dose LPS (10 μg) and OVA induced asthma phenotypes with noneosinophilic airway inflammation [43]. This evidence concerns the gene IGHE and asthma.