This increasement in adipocyte size was also observed when high fat diets (HF) were administered to rats [5], in which 51% of the energy was derived from fats, and they observed that an increase in adipocyte size occurred, and as a consequence, an increase in inflammatory cytokines (NF-γ, IL-6 e TNF-α) was observed, as shown in Table 6. Here, TNF is linked to hydrops fetalis.