In this case, this process is called hypercholesterolemia, which is the accumulation of low density lipoprotein (LDL) in the plasma by alterations in the genes of the LDL receptor (LDLR), or apolipoprotein B-100, which is considered as one of the most important components of atherogenic lipoproteins [55]. The gene discussed is LDLR; the disease is Hypercholesterolemia.