EIF2AK3 and early-onset autosomal dominant Alzheimer disease: There are literary data supposing that the eIF2α kinase responsible for this regulation may be PERK: in the hippocampal area CA1 of APP/PS1 mice (an animal model of Alzheimer’s disease), PKMζ concentration is reduced, and conditional deletion of PERK restored PKMζ expression back to the normal level [31].