As for CHOP, in the described above work with an Alzheimer’s disease animal model, CHOP concentration was found to be unaltered in APP/PS1 mice with conditional PERK knock-out compared to APP/PS1 mice [31], so we may speculate that PERK is not important for CHOP translation regulation. This evidence concerns the gene PSEN1 and early-onset autosomal dominant Alzheimer disease.